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Clozapine 8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
C18H19ClN4, M = 326,82 g/mol

Antipsychotic (atypical neuroleptic)

Brand Names: Clozaril®, Leponex®. Tablets with 25, 50 or 100 mg clozapine.


Treatment of acute or chronic schizophrenia, especially in treatment-restistant cases. Beginning with a dose of 12,5 mg, slowly increased to 200 up to 450 mg/day but not over a maximum of 600 mg/day. Half life 6 to 25 hours. Clozapine was already synthetisized in 1960 and available from 1971. It is the only atypical neuroleptic without appearance of extrapyramidal-motoric disorders.


Do not use in cases of blood disturbances, especially leucozytic disorders. High risk of agranulozytosis in the first 18 weeks of consumption.

Adverse effects

Sedation, tremors, obstipation, weight gain.


Therapeutic blood level 0,03 to 0,06 µg/ml

Overview antipsychotics

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ