German Version French Version

codeine 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ole C18H21NO3, M = 317,39 g/mol

The name Codeine derives from the greek "Kodeia" = poppy cap. It is an Opium alkaloid contained from 0.3 to 3 percent in the liquid opium extract, where it was discovered 1833 by Robiquet. Codeine is a week analgesic, but mainly used as antitussive. Codein partly metabolised in the liver (O-demethylation) at the enzyme Cytochrom P-450 CYP2D6 to morphine. Therefore positive results in opiat urine testing must be absolutely examined therefore by GC/MS analysis. As further metabolite Norcodein appears by N-demethylation.

In the United Kingdom, codeine is a Class B Drug, regulated by the Misuse of Drugs Act 1971. Combinations with paracetamol in high dosage are used as recreational drug, despite the risk of the hepatotoxicity of paracetamol.

Custom Search




Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ