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Morphine 7,8,-Didehydro-4-α-epoxy-17-methyl-3,6-mophinandiole, C17H19NO3, M=285,33 g/mol

"Morphium" was isolated for the first time 1806 from Friedrich William Sertuener. Pure morphine releases the same physiological effects as Opiate, however, it works substantially more strongly. It is an euphoric and pain killing drug, without switching consciousness off completely. Morphine is iv-injected in acute pain therapy, for long-term treatment will morphine be given in tablet form, with less acute cases also by subcutan injection.

The effect remains only 3-4 hours. Retard tablets with 10 to 200 mg morphine content (morphine sulfate) release the active substance slowly and make in such a way pain liberty during longer periods possible (preparations[GB]: MST Continus, Oramorph, Sevredol). As adverse effect with long-term consumption an intestine inertia often becomes up , which leads to blockage. As remedy can be fallen back to synthetic Opioide (Buprenorphin, Fentanyle), which can be used also as plasters.

With illegal heroin consumption morphine is formed very rapidly in the body by the specific intermediate stage of the metabolite mono acetyl morphine (MAM). Morphine is formed, however, also by codeine consumption. The differentiation between heroin and codeine consumption can take place therefore with positive morphine findings only via the simultaneous proof of MAM by means of GC/MS as specific heroin dismantling product.

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ