Paroxetine
(3S,4R)-4-(4-Fluorphenyl)-3-{[3,4-methylendioxy)phenoxy]methyl}piperidin, C19H20FNO3, MW 329,37 g/mol
Selective Serotonin Reuptake Inhibitor (SSRI)
Trade Mark: Paxil®, Seroxat®, Tagonis®
Application
Treatment of depressive illnes, obsessive-compulsive disorder, panic disorder, social phobia, post-traumatic stress disorder, generalised anxiety disorder. Contraindicated for patients under 18 years of age (high suicide risk)
Interactions
Do not use with MAO inhibitors, because of the danger of a Serotonine syndrome.
Adverse Effects
Especially at the beginning, nausea can occur. When setting off, reduce dose slowly, increased risk of suicides.
Analytics
The determination of Paroxetine can take place after extraction by means of HPLC/DAD. Therapeutic levels: 0.01-0.05 µg/ml.
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