Trazodone, 2-{3-[3-Chlorophenyl)piperaz-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3-one, C19H22ClN5O, MW 371,86 g/mol
Trazodone is an antidepressant with a rapid taken effect (about 1 week), acting both as a serotonin reuptake inhibitors (SSRI) as well as 5HT2 receptor antagonist. In contrast to the tricyclic antidepressants trazodone has no anticholinergic activity.
Trade names: Desyrel™, Molipaxin™, Trittico™, Thombran™, Trialodine™
Usage
Tablets or capsules with 100 mg for the treatment of depressive disorders, including sleep disorders. Together at the start of SSRI treatment applicable.
Interactions
Increased efficiency together with CNS-effectve drugs and alcohol.
Adverse Effects
Not contra-indicated in cases of glaucome.
Analytics
Intensive metabolisation by oxidation and hydrolysis, main metabolite: m-Chlorophenyl-piperazine. Therapeutic Blood-/Plasma level 0.8 to 1.6 µg/ml, respectively.
