German Version

Trazodone Trazodone, 2-{3-[3-Chlorophenyl)piperaz-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3-one, C19H22ClN5O, MW 371,86 g/mol

Trazodone is an antidepressant with a rapid taken effect (about 1 week), acting both as a serotonin reuptake inhibitors (SSRI) as well as 5HT2 receptor antagonist. In contrast to the tricyclic antidepressants trazodone has no anticholinergic activity.

Trade names: Desyrel, Molipaxin, Trittico, Thombran, Trialodine


Tablets or capsules with 100 mg for the treatment of depressive disorders, including sleep disorders. Together at the start of SSRI treatment applicable.


Increased efficiency together with CNS-effectve drugs and alcohol.

Adverse Effects

Not contra-indicated in cases of glaucome.


Intensive metabolisation by oxidation and hydrolysis, main metabolite: m-Chlorophenyl-piperazine. Therapeutic Blood-/Plasma level 0.8 to 1.6 µg/ml, respectively.


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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ