Trazodone
 
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Trazodone Trazodone, 2-{3-[3-Chlorophenyl)piperaz-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3-one, C19H22ClN5O, MW 371,86 g/mol

Trazodone is an antidepressant with a rapid taken effect (about 1 week), acting both as a serotonin reuptake inhibitors (SSRI) as well as 5HT2 receptor antagonist. In contrast to the tricyclic antidepressants trazodone has no anticholinergic activity.

Trade names: Desyrel, Molipaxin, Trittico, Thombran, Trialodine

Usage

Tablets or capsules with 100 mg for the treatment of depressive disorders, including sleep disorders. Together at the start of SSRI treatment applicable.

Interactions

Increased efficiency together with CNS-effectve drugs and alcohol.

Adverse Effects

Not contra-indicated in cases of glaucome.

Analytics

Intensive metabolisation by oxidation and hydrolysis, main metabolite: m-Chlorophenyl-piperazine. Therapeutic Blood-/Plasma level 0.8 to 1.6 µg/ml, respectively.

 

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ