Bromazepam

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Bromazepam

Bromazepam, 7-Brom-2,3-dihydro-5-(2-pyridyl)-1H-1,4-benzodiazepine-2-one
C15H10BrN3O, MW 316,2 g/mol

1,4-Benzodiazepine (ultralong-working) T 1/2 15 to 28 hours

Trade Marks: Bromazanil®, Durazanil®, Gityl®, Lexotanil®, Normoc® (numerous generics)

Application

For the symptomatic treatment of acute and chronic tension, excitation and fear conditions (tranquilizer). Bromazepam acts by increasing the activity of GABA.

Warnings

Do not use during pregnancym or breastfeeding.

Reciprocal effects

Bromazepam strengthens the effect of many other CNS medicaments. The effect of Bromazepam is strengthened by alcohol.

Adverse Effects

Bromazepam impairs reactivity and causes with uptake over a longer period a psychological and, in addition, physical dependence. When suddently set off withdrawal symptoms arise.

Analytics

Therapeutic blood levels: 0.08 to 0,2 µg/ml.

History

Bromazepam was first synthesized in 1974 by Hoffmann LaRoche and marked under the label Lexotanil®.

Overview Benzodiazepines