Abbreviation for Δ-9-Tetrahydrocannabinol, the main physiologically effective component of the Cannabis rsp. hashish. It metabolised mainly to 11-Hydroxy-THC and further to 11-Carboxy-THC, which is provable in the blood enzyme-immunoassay for several hours, by GC/MS (cut off 5 µg/l) still up to 25 days, while the concentrations of THC and 11-Hydroxy-THC decrease rapidly. 70% of the THC dose are separated within 72 h (40% into the feces, 30% into the urine as conjugate). The proof of a long-term consumption is possible by means of hair analysis, whereby a hair length of each cm corresponds to a further past month.
The biological effect of the THC takes place to the CB1 and CB2-Cannabinoid-Receptors, which play an important role for emotion control (fear conditions). As endogenous (body-own) Cannabinoids the Anandamide (1992) and the 2-Arachidonoylglycerol (2-AG, 1995) were isolated.
THC is often used by HIV infected persons against nausea and for the appetite increase. In recent clinical studies of the University of California (Ann. Int. Med., 139, 258-266, 2003) the fear, THC could lower the effect of the protease inhibitors through concurrent dismantling given in the antiretroviral therapy to the P450-enzyms,was not confirmed. With inhalational (joint) as well as oral (Dronabinol) admission of THC a stabilization of the immune system as well as increasing weight was observed.