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3,4,5,-Trimethoxyphenethylamine. Mescaline is an alkaloid from the cactus Peyotl (botanical name: Lophophora Williamsi), which mainly grows in Mexico. It was used as ritual drug by the indians for their ceremonies. Mescalin is also found in the cactus Trichocereus pachanoi and Trichocereus peruvianus.


Mescaline is distributed in the body like LSD. The highest concentration where found in liver and kidneys, the lowest in brain. 30 minutes after uptake it is fully eliminated. The toxical dosage is above 100 mg.

Psychedelic Effects

The psychedelic effect are likeswise the hallucinogenic effects of LSD, parapsychedelic experiences were described, possibly induced by eliminatinon of outer stimulation of senses and a strong orientation to the "inner universe" (Schmidbauer, v.Scheidt, 1989). Also Alexander Shulgin reports his experience with mescaline. See also phenethylamines.


Mescaline was the first extracted in 1896. In 1919 it became the first psychedelic to be synthesized. In 1953 Aldous Huxley, after trying 0.4 g of mescaline by himself, wrote "The Doors of Perception: And Heaven and Hell".

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