German Version French Version

Amitriptyline 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yliden)-N,N-dimethylpropylamine

Amitriptyline is a Tricyclic Antidepressant Drug first synthesized in 1960. It is administered either orally or by intramuscular injection.

Serum half-life has been found in the range of 8 to 51 hours, its metabolites up to 30 hours.

Trade-Marks: GB: Elavil®, international: Laroxyl®, Saroten®, Tryplizol®

Strong interactions with MAO-Inhibitors up to delir or coma.

Amitriptyline is extensivly metabolized to more polar compouds. Major metabolite is nortriptiline which may be largely responsible for the antidepressive effect.

Therapeutic blood level: 0,05-0,3 µg/ml.

Custom Search




Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ