Amitriptyline is a Tricyclic Antidepressant Drug first synthesized in 1960. It is administered either orally or by intramuscular injection.
Serum half-life has been found in the range of 8 to 51 hours, its metabolites up to 30 hours.
Trade-Marks: GB: Elavil®, international: Laroxyl®, Saroten®, Tryplizol®
Strong interactions with MAO-Inhibitors up to delir or coma.
Amitriptyline is extensivly metabolized to more polar compouds. Major metabolite is nortriptiline which may be largely responsible for the antidepressive effect.
Therapeutic blood level: 0,05-0,3 µg/ml.