Oxycodone
 
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Oxycodone (5R,9R,13S,14S)14-Hydroxy-3-methoxy-17-methyl-4,5-epoxymorphinan-6-on C18H21NO4, M 315,36 g/mol

Oxycodone is a semi-synthetic opioid used as orally active analgesic (3-fold strenght of morphine). It is marked, among others, as Oxycontin. In the UK it is a Class A drug under the Misuse of Drugs Act 1971. Preparations include a combination with acetaminophen (Percocet, Endocet, Roxicet, Tylox), but also aspirin (Percodan, Endodan, Roxiprin) or ibuprofen (Combunox), to provide an increased analgetic effect by synergy. More important, it limits the intake of oxycodone by causing unpleasant Adverse Effects up to severe hepatotoxicity by overdosage over a long time period.

Acute overdosage symptoms are respiratory depression, somnolence, coma, stupor.

Therapeutic blood levels are 0.02 up to 0.05 µg/ml, in fatal cases above 0.6 µg/ml.

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ