Tricyclic Antidepressants
 
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According their special chemical structure nominated class of Antidepressants which act unspecifically with all kinds of neurotransmitter. Therefore secondary reaction often arises. Cases of deadly intoxication by over-dosage are well known. Physostigmine is used as antidote.

Amitriptyline

Amitriptyline

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yliden)-N,N-dimethylpropylamine, C20H23N, M=277,39 g/mol
Tricyclic Antidepressant, first synthetisized in 1960,Half-time 8 to 51 hours, Metabolits 30 hours.
Trade-Marks: GB: Elavil®, international: Laroxyl®, Saroten®, Tryplizol more

Clomipramine

Clomipramine

[3-(3-Chlor-10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]dimethylazane, C19H23ClN2, M=314,87 g/mol
Trade-Marks: Anafranil®, Hydiphen® more

Desipramine

Desipramine

5-(3-Methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine, C18H22N2, M=266,37 g/mol
Trade-Marks: Norpramin®, Pertofran®, Petyly®

Dibenzepine

Dibenzepine

10-[2-(Dimethylamino)ethyl]-10,11-dihydro-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one, C18H21N3O, M=295,37 g/mol
Trade-Marks: Noveril®

Doxepin

Doxepin

3-(6,11-Dihydrodibenz[b,e]oxepin-11-yliden)-N,N-dimethylpropylamine, C19H21NO, M=279,37
Tricylic Antidepressant, first synthetisized in 1962, half-time 11-19 h, Metabolits 40 h. Specially used by depressions- or fear-syndroms.
Trade-Marks: Aponal®, Desidox®, Doneurin®, Doxepin AZU®, Doxepin beta®, Doxepin dura®, Doxepin neurapharm®, Doxepin ratiopharm®, Doxepin STADA®, Doxepin TEVA®, Mareen®, Sinquan®.
Dosis Grown-ups beginning with 75-150 mg/d, stationary up to 300 mg/d. In case of over-dosage: excitation, halluzinations, tachycardy and hypertension, death cases known. more

Imipramine

Imipramine

5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine, C19H24N2, MW 280,40
Trade-Marks: Efuranol®, Imipramin-neuraxpharm®, Tofranil®

Lofepramine

Lofepramine

4'-Chloro-2-{[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino}-acetophenon, C26H27ClN2O, M=418,97 g/mol
Trade-Marks: Gamonil®

Nortriptyline

Nortriptyline

N-Methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yliden)propylamin, C19H21N, M=263,37 g/mol
Trade-Marks: Nortrilen®

Opipramol

Opipramol

4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazinethanol, C23H29N3O, MW 363,49
Trade-Marks: Insidon®, Opipramol-neuraxpharm® more

Trimipramine

Trimipramine

3-(10,11-Dihydro-5H-dibenz[b,f]azepin-5-yl)-2,N,N-trimethylpropylamin, C20H26N2, M=294,42 g/mol
Trade-Marks: Stangyl®, Trimineurin®, Trimipramin-neuraxpharm®

see also Antidepressants, Tetracyclic Antidepressants, SSRI, SNRI

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ