Maprotiline, N-Methyl-3-(9,10-dihydro-9,10-ethano-9-anthracenyl)proylamine, C20H23N, M 277,41 g/mol
Trade Marks: Ludiomil®, Maprolu®
Application
Treatment of depressions, sleeping disturbance and loss of appetite.
Contraindications
Do not use during pregnancy. Do not use by suffering from epilepsy, hypotension or glaucoma.
Interactions
Benzodiazepines, alcohol and histamines are effect-strengthening. Combination with MAO inhibitors cause fever, cramps and unconsciousness.
Adverse Effects
The following symptoms can occur in connection with Maprotiline: Tiredness, mouth dryness, stomach intestine disturbances, problems with urination, visual disturbances, release of a glaucoma, heart lawn and heartbeat disturbances, reduced blood pressure, swindle, unrest, sleep disturbances, muscle tremor, allergic skin reactions.
Analytics
The blood level determination of Maprotiline can take place after extraction by means of HPLC/DAD. Therapeutic blood levels: 0.1-0.6 µg/ml.
Medicaments
Maprotiline
