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Doxepine Doxepin, 3-(6,11-Dihydrodibenz[b,e]oxepin-11-ylidene)-N,N-dimethylpropylamine, C19H21NO, M 279,37 g/mol

Tricyclic Antidepressant, first synthetisized in 1962. Half-life 11-19 hours (Metabolite Nordoxepine 40 hours)

Trade marks: Aponal®, Desidox®, Doneurin®, Mareen®, Sinquan®


Treatment of depression, anxiety, sleep disturbances.

Reciprocal effects

Strong anticholinergic side effects (tachycardie, hypotension) up to pharmacogenic delir. do not use during pregnancy or lactation period.

Adverse Effects

Strong interaction with MAO inhibitors.


Determination of Doxepine by HPLC/DAD. Therapeutic blood level 0,01-0,2 µg/ml, Metabolite Nordoxepine 0,05-0,15 µg/ml.

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ