SSRI
 
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The neurotransmitter serotonine plays an important role with depressive disturbances and other psychological illnesses, as the serotonine level is reduced in the synaptic gap. While the classical uptake of tricyclic and tetracyclic antidepressants influences all messenger materials of the brain, the SSRI affects the serotonine specifically, as the connection at the receptors of the nerve cell is prevented and more serotonine is thus available. Higher specificity permits a lower concentration and reduces thus the adverse effects (nausea, sleep disturbances), which arise occasionally at the beginning of the therapy.

A possible adverse effect common to all selective serotonin reuptake inhibitors is the so-called "Serotonin syndrome", consisting of confusion, agitation, hyperreflexia, sweating, tremor, fever and diarrhoea.

Several instistutions are warning of the employment of SSRI with young people however, because of the increase of the suicid risk. SSRI gift to young animals caused a later gene defect of the adult animals, resulting in a disturbance of the serotonine transport mechanism, which is still to a large extent unclear. At present, no serotonine deficit could be proven as a cause of a depression clearly. Tries to cause a depression by decreasing of the serotonine level artificially so far failed. The Academy for Entireness Medicine in Vienna warns that it is not goal-prominent, to take a well compatible medicine for tendency change instead to employ itself with the actual problems.

Citalopram

Citalopram / Escitalopram

1-[3-(Dimethylamino)propyl]-1-(4-fluorphenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, C20H21FN2O, M=324,40 g/mol
Trade Mark (Citalopram): Cipramil®, Celexa®
Escitalopram (S-isomer of Citalopram): lexapro®, Cipralex® more

Fluoxetine

Fluoxetine

(RS)-N-Methyl-3-phenyl-3-(4-trifluormethylphenoxy)propylamine, C17H18F3NO, M=309,33 g/mol
Trade Mark: Prozac® more

Fluvoxamine

Fluvoxamine

(E)-5-Methoxy-4'-(trifluormethyl)valerophenon-O-(2-aminoethyl)oxim, C18H21F3N2O2, M=318,35 g/mol
Trade mark: Luvox® more

Paroxetine

Paroxetine

(3S,4R)-4-(4-Fluorphenyl)-3-{[3,4-methylendioxy)phenoxy]methyl}piperidin, C19H20FNO3, M=329,37 g/mol
Trade Mark: Paxil®, Seroxat®, Tagonis® more

Sertraline

Sertraline

(1S,4S)-4-(3,4-Dichlorphenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtylamine, M=306,23 g/mol
Trade Mark: Zoloft®, Gladem® more

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ