1-{[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl}-4-methylpiperazine, C28H38N6O11S, M=474,58 g/mol
Type: PDE Type 5 Inhibitor)
Trade Names: Viagra®, Revatio®
Sildenafil is used for the treatment of erectile dysfunction and pulmonary arterial hypertonia. Half life 4-6 hours. Effects only after sexual stimulation.
Do not use Sildenafil together with nirate containing medicines or other NO donatating agents ( p.e. Poppers)!
Effects increased with Cimetidine
Headache
Therapeutic blood level 0,0005 up to 0,01 µg/ml. Sildenafil is metabolised by hepatic enzymes (N-demethylation) and excreted by both the liver and kidneys.