(5R,9R,13S,14R)-3-(Methoxy-17-methyl-4,5-epoxymorphinan-6-on C18H21NO3, M 299,36 g/mol
Hydrocodone is a semi-synthetic opioid used as orally active narcotic and analgesic. It is marked, among others, as Vicodin, Anexsia or Dicodid. In the UK it is a Class A drug under the Misuse of Drugs Act 1971. Preparations include a combination with acetaminophen, but also aspirin or ibuprofen, to provide an increased analgetic effect by synergy. More important, it limits the intake of hydrocodone by causing unpleasant Adverse Effects up to severe hepatotoxicity by overdosage over a long time period.
The daily consumption should not exceed 40 mg/day without tolerance to opiates. However, chronic pain patients are given up to 180 mg/day. Acute overdosage symptoms are respiratory depression, somnolence, coma, stupor.
Therapeutic blood levels are 0.01 up to 0.05 µg/ml, in fatal cases above 0.2 µg/ml.