C9H7Cl2N5, M=256,09 g/mol
Trade Mark: Lamictal®
Long-term treatment of epilepsy as well as depression and bipolar disorders. Lamotrigine is blocking the sodium and calcium channels of the nerve cells and prevents the release of exiting transmitters (p.e, glutamate). Slow increasing dosage (25 mg increase per 14 days), until a daily dose of 100-200 mg is reached.
Delayed degradation in the presence of sodium valproate. Accelerated degradation with paracetamol. Mutual disorders and side effects when used together with Anticonceptives.
Lamotrigine is generally well tolerated. Too fast dosage increasement may cause redness.
The blood level determination of Mirtazapine can take place after extraction by means of HPLC/DAD. Therapeutic blood levels: 3-14 µg/ml.