Lamotrigine, 6-(2,3-Dichlorophenyl)-1,2,4-triazin-3,5-diamine
C9H7Cl2N5, M=256,09 g/mol
Phenyltriazine
Trade Mark: Lamictal®
Application
Long-term treatment of epilepsy as well as depression and bipolar disorders. Lamotrigine is blocking the sodium and calcium channels of the nerve cells and prevents the release of exiting transmitters (p.e, glutamate). Slow increasing dosage (25 mg increase per 14 days), until a daily dose of 100-200 mg is reached.
Interactions
Delayed degradation in the presence of sodium valproate. Accelerated degradation with paracetamol. Mutual disorders and side effects when used together with Anticonceptives.
Adverse Effects
Lamotrigine is generally well tolerated. Too fast dosage increasement may cause redness.
Analytics
The blood level determination of Mirtazapine can take place after extraction by means of HPLC/DAD. Therapeutic blood levels: 3-14 µg/ml.
