Olanzapine
 
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Olanzapine Olanzapine, 2-Methyl-10-(4-methylpiperazin-1-yl)-4H-3-thia-4,9-diazabenzo[f]azulene
C17H20N4S, M=312.44 g/mol

atypical antipsychotic

Trade Mark: Zyprexa

Application

Treatment of schizophrenia and bipolar mania. Initial dose 10 mg, thereafter 20 mg. The maximum level is reached after 5-8 hours, half-life 21 up to 54 hours.

Contraindications

Do not use with older dementia patients as well as cases of glaucoma.

Interactions

Accelerated metabolism with simultaneous use of Carbamazepine, slowed down metabolisms with Fluvoxamine.

Adverse Effects

Substantial weight gain with increased diabetic risk, since Olanzapine intervenes in the insulin metabolism.

Analytics

Therapeutic levels: 0.02 up to 0.03 µg/ml (serum/plasma).

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Last modification (M-D-Y): 02/08/2019 - IMPRINT - FAQ